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Salerno, E. V.; Eliseeva, S. V.; Schneider, B. L.; Kampf, J.W.; Petoud, S.; Pecoraro, V. L. Visible, Near-Infrared, and Dual-Range Luminescence Spanning the 4f Series Sensitized by a Gallium(III)/Lanthanide(III) Metallacrown Structure. J. Phys. Chem. A 2020, 124(50), 10550-10564
Welcome !
The goal of the « Luminescent lanthanide compounds, optical spectroscopy and bioimaging » team is to create new luminescent molecules, macromolecules and nanomaterials, the design of which is taking into account the requirements of optical biological imaging, in vitro and in vivo.
We combine multidisciplinary expertise in organic and inorganic synthesis, visible and near-infrared advanced spectroscopy (absorbance and luminescence), biochemistry, cellular and small animal imaging and instrument development.
Luminescent Probes and Sensors Based on Lanthanides for Biological Imaging
The creation of novel luminescent reporters and sensors based on lanthanide cations emitting in the visible and in the near-infrared is the major component of the research program. Our objective is to design, synthesize and study lanthanide compounds which possess novel or improved luminescence properties that address the requirements of analysis in biological conditions where a significant fluorescent background is present. In addition, we test and use our lanthanide compounds in practical applications such as bioanalytical assays and optical imaging at the cellular and small animal levels with a special interest for the detection in the NIR I and NIR II spectral domains.
We are also interested in the creation of lanthanide-based compounds suitable for multimodal detection, in particular, NIR luminescence combined with photoacoustic, MRI and/or SPECT imaging.
To achieve these goals, we are investigating different families of lanthanide-based compounds: small molecular complexes, dendrimers, nanocrystals, nanoparticles, metal-organic frameworks, micelles and microemulsions.
In addition, the team is coordinating the optical platform of the CBM. The goal of this platform is to provide to internal and external user advanced spectroscopic instrumentation and, if required, the required training.